The Jabez Smith Building is a certified historical structure within Petersburg's Historic Old Towne District.
Jabez Smith first used the building as part of his cotton mill operation in the 1820s. It is unclear how long Smith's operations occupied the building, but his business was very successful in the area. Since Smith's business, the building survived the Civil War, was spared during Petersburg's random demolition of historic buildings during the mid-twentieth century, and withstood the 1993 tornado that unexpectedly ripped through the downtown area.
From the 1990s to 2014, the building was used as medical offices, including the Appomattox Dialysis Center.
Now, the building is a mixed-use space used for commercial and residential purposes.